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引用本文:   黄煜宇, 肖坤, 裴兴丽, 韩玉良, 龚灿, 许旭. 使用尖玻片、毛细管和尖滴管三种玻璃尖端电喷雾离子化质谱分析方法. 分析化学, 2018, 46(4): 578-585. doi:  10.11895/j.issn.0253-3820.171305 [复制]

Citation:   HUANG Yu-Yu, XIAO Kun, PEI Xing-Li, HAN Yu-Liang, GONG Can, XU Xu. Three Glass Electrospray Ionization Devices for Direct Mass Spectrometry Analysis Using Sharp Slide, Slender Capillary and Sharp Dropper. Chinese Journal of Analytical Chemistry, 2018, 46(4): 578-585. doi: 10.11895/j.issn.0253-3820.171305 [复制]

使用尖玻片、毛细管和尖滴管三种玻璃尖端电喷雾离子化质谱分析方法

通讯作者:  许旭, xuxu3426@sina.com; xuxu@sit.edu.cn

收稿日期: 2017-10-09

接受日期: 2018-01-10

出版日期: 2018-04-01

基金项目: 本文系国家自然科学基金项目(No.31671928)和上海市自然科学基金项目(No.15ZR1440800)资助

Three Glass Electrospray Ionization Devices for Direct Mass Spectrometry Analysis Using Sharp Slide, Slender Capillary and Sharp Dropper

Corresponding author:  XU Xu, xuxu3426@sina.com; xuxu@sit.edu.cn

Received Date:  2017-10-09

Accepted Date:  2018-01-10

Published Date:  2018-04-01

Fund Project:  This work was supported by the National Natural Science Foundation of China (No.31671928) and Natural Science Foundation of Shanghai, China (No.15ZR1440800)

建立了用于质谱分析的尖玻片、毛细管、尖滴管3种基于玻璃尖端电喷雾的离子化新方法。通过模拟实验与实际质谱实验,考察了各种实验条件的影响。在喷雾尖端直径小于0.24 mm时,选择喷雾尖端针与反相电极距离10 mm,喷雾电压4.5 kV,喷雾尖端角度为后部偏上5.0°(尖玻片)~7.5°(细毛细管或尖滴管)、左右角度为0°(均对准中间)。选择奎宁、扁桃酸、安息香、苯丙氨酸等不同类型样品的溶液(正离子检测含1%甲酸,负离子检测含1%氨水)置于玻片上或者毛细管与尖滴管后部容器中,进行尖端喷雾直接分析。样品在正离子与负离子模式下分别得到了相应的质谱信号。尖玻片喷雾适合比较稳定、对空气不敏感的样品;毛细管喷雾和尖滴管喷雾则适合分析粘度较低,甚至不稳定的样品溶液。使用本方法实际分析了盐酸普萘洛尔和盐酸小檗碱片剂的提取溶液。3种玻璃尖端电喷雾方法均不需要载气,结构简单、易于构建、操作方便快速,可方便地用于样品溶液的质谱分析。

关键词:   质谱离子化, 质谱进样, 尖端喷雾, 玻璃喷雾
Key words:   Mass spectrometry ionization, Mass spectrometry injection, Sharp electrospray, Glass electrospray
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目录

使用尖玻片、毛细管和尖滴管三种玻璃尖端电喷雾离子化质谱分析方法

黄煜宇, 肖坤, 裴兴丽, 韩玉良, 龚灿, 许旭

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