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引用本文:   赵丽萍, 杨歌, 张小敏, 屈锋. 蛋白质的核酸适配体筛选及应用的研究进展. 分析化学, 2020, 48(5): 560-572. doi:  10.19756/j.issn.0253-3820.201024 [复制]

Citation:   ZHAO Li-Ping , YANG Ge , ZHANG Xiao-Min , QU Feng . Development of Apatmer Screening Against Proteins and Its Applications. Chinese Journal of Analytical Chemistry, 2020, 48(5): 560-572. doi: 10.19756/j.issn.0253-3820.201024 [复制]

蛋白质的核酸适配体筛选及应用的研究进展

收稿日期: 2020-01-09

基金项目: 本文系国家自然科学基金项目(Nos.21675012,21874010,21827810)资助

Development of Apatmer Screening Against Proteins and Its Applications

Received Date:  2020-01-09

Fund Project:  This work was supported by the National Natural Science Foundation of China (Nos. 21675012, 21874010, 21827810).

核酸适配体是通过指数富集配体系统进化(SELEX)筛选方法获得的,能够与靶标分子高亲和力和特异性结合的单链DNA或RNA。蛋白质是一种非常重要的生物功能大分子,迄今为止,已经开发了许多SELEX技术,用于蛋白质的适配体的筛选。目前,适配体的筛选优化方法主要集中在提高筛选效率、降低筛选成本,以及提升适配体性能等方面,从而获得可与靶标分子以高亲和力和高特异性结合的适配体。适配体与靶标分子亲和力的表征是关键的筛选步骤,用于判定所筛选的适配体是否可以满足后续应用需求。本文归纳总结了2016年以来蛋白质靶标的适配体筛选的研究进展,对核酸适配体筛选过程中有关核酸库的优化方法和筛选方法的改进、新筛选方法的开发、核酸适配体的应用等方面的研究进行了评述。

关键词:   核酸适配体, 蛋白质, 筛选, 指数富集配体系统进化, 评述
Key words:   Aptamer, Protein, Selection, Systematic evolution of ligands by exponential enrichment, Review
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蛋白质的核酸适配体筛选及应用的研究进展

赵丽萍, 杨歌, 张小敏, 屈锋

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