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引用本文:   崔琳, 赵敏惠, 张春阳. 主客体作用在生化分析中的应用研究进展. 分析化学, 2020, 48(7): 817-826. doi:  10.19756/j.issn.0253-3820.201090 [复制]

Citation:   CUI Lin , ZHAO Min-Hui , ZHANG Chun-Yang . Recent Advance in Applications of Host-Guest Interaction in Biochemical Analysis. Chinese Journal of Analytical Chemistry, 2020, 48(7): 817-826. doi: 10.19756/j.issn.0253-3820.201090 [复制]

主客体作用在生化分析中的应用研究进展

通讯作者:  张春阳, cyzhang@sdnu.edu.cn

收稿日期: 2020-02-20

基金项目: 本文系国家自然科学基金(Nos.21735003,21527811,21605096,21974080)和山东省泰山学者优势特色学科人才团队项目资助

Recent Advance in Applications of Host-Guest Interaction in Biochemical Analysis

Corresponding author:  ZHANG Chun-Yang , cyzhang@sdnu.edu.cn

Received Date:  2020-02-20

Fund Project:  This work was supported by the National Natural Science Foundation of China (Nos. 21735003, 21527811, 21605096, 21974080) and the Award for Team Leader Program of Taishan Scholars of Shandong Province, China.

主客体作用是主体和客体在满足结构互补和能量匹配的条件下,通过非共价相互作用选择性结合,形成具有特定功能的超分子的过程。生物体系中的抗原-抗体、DNA-蛋白质、酶-底物等生物分子之间的识别都建立在非共价作用识别的基础上。主客体识别反应具有反应条件温和、反应过程动态可逆等特点,不仅可有效克服共价结合的局限性,而且能在分子水平上模拟生物功能。本文综述了主客体作用在生化分析中的应用的最新研究进展,并对基于主客体作用的传感器的发展趋势做了展望。

关键词:   主客体作用, 生物传感器, 超灵敏检测, 生化分析, 评述
Key words:   Host-guest interaction, Biosensors, Biochemical analysis, Sensitive detection, Review
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目录

主客体作用在生化分析中的应用研究进展

崔琳, 赵敏惠, 张春阳

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