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引用本文:   古连城, 周爱南, 陈新, 吴芳玲, 李建其, 余绍宁, 周鸣飞, 丁传凡. 利用非共价复合物实现对布洛芬分子的手性分析. 分析化学, 2021, 49(1): 95-102. doi:  10.19756/j.issn.0253-3820.201477 [复制]

Citation:   GU Lian-Cheng , ZHOU Ai-Nan , CHEN Xin , WU Fang-Ling , LI Jian-Qi , YU Shao-Ning , ZHOU Ming-Fei , DING Chuan-Fan . Chiral Analysis of Ibuprofen through Non-covalent Complexes. Chinese Journal of Analytical Chemistry, 2021, 49(1): 95-102. doi: 10.19756/j.issn.0253-3820.201477 [复制]

利用非共价复合物实现对布洛芬分子的手性分析

通讯作者:  李建其, lijianqb@126.com; 丁传凡, dingchuanfan@nbu.edu.cn

收稿日期: 2020-08-07

基金项目: 国家自然科学基金项目(Nos.21773035,21803013)资助。

Chiral Analysis of Ibuprofen through Non-covalent Complexes

Corresponding author:  LI Jian-Qi , lijianqb@126.com; DING Chuan-Fan , dingchuanfan@nbu.edu.cn

Received Date:  2020-08-07

Fund Project:  Supported by the National Natural Science Foundation of China (Nos.21773035, 21803013).

手性药物的检测对于深入了解药物作用机理具有十分重要的意义。布洛芬(Ibuprofen)是常用的临床消炎药物,具有R型和S型两种构型,但其消炎作用却几乎全部由S-布洛芬所提供。本研究建立了一种区分布洛芬手性的方法,将布洛芬对映体与γ-环糊精及BaCl2混合,得到系列非共价复合物,利用捕集离子淌度质谱(Trapped ion mobility spectrometry-time-of-flight mass spectrometry,TIMS-TOF MS)测量各物质的离子淌度(Ion moboility)。采用TIMS-TOF MS成功分离了非对映体离子[γ-CD+R-Ibuprofen+Ba(BaCl)-H]2+与[γ-CD+S-Ibuprofen+Ba(BaCl)-H]2+,碰撞截面的差值高达0.07 nm2。此外,实验结果表明,一系列[γ-CD+S-Ibuprofen+Ba(BaCl)-H]2+的离子淌度谱峰强度分数与其摩尔分数呈线性关系。本方法无需对样品分子进行前处理或化学衍生化,可以快速、高效地分析手性分子。

关键词:   布洛芬, γ-环糊精, 氯化钡, 非共价复合物, 手性分析, 捕集离子淌度质谱
Key words:   Ibuprofen, γ-Cyclodextrins, Barium chloride, Non-covalent complex, Chiral analysis, Trapped ion mobility spectrometry-time-of-flight mass spectrometry
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目录

利用非共价复合物实现对布洛芬分子的手性分析

古连城, 周爱南, 陈新, 吴芳玲, 李建其, 余绍宁, 周鸣飞, 丁传凡

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