Citation: Zhu Jingping , Chen Hengwu , Fang Qiongjun . Flow Injection Photochemical-Spectrofluorimetric Determination of Chlorpromazine in Pharmaceutical Preparations. Chinese Journal of Analytical Chemistry, 1997, 25(5): 573-575. [复制]
Flow Injection Photochemical-Spectrofluorimetric Determination of Chlorpromazine in Pharmaceutical Preparations
Flow injection-photochemical reaction of chlorpromazine was carried out in a knotted reactor that was coiled around a fluorescent lamp and irradiated by its UV light with the emission maximum at 365 nm.The fluorescence of the photochemical reaction product was on-line measured at the excitation wavelength of 253 nm and the emission wavelength of 374.5 nm.Under the optimized condition,a detection limit (3σ) of 5.4 μg/mL was achieved at a sample throughput rate of 90/h,and a relative standard deviation of 0.5% obtained at the analyte concentration of 1 mg/L (n=11).Linear dynamic range was 0.01~6.00 μg/L.The proposed mothed has been successfully appllied to the determination of chlorpromazine hydrochloride contents in tablets and injections.